Paulo Rodrigues Santos - Publications

Latest Publications

Casanova JM, Almeida JS, Reith J, Sousa LM, Fonseca R, Freitas-Tavares P, Santos-Rosa M, Rodrigues-Santos P.
Tumor-infiltrating lymphocytes and cancer markers in osteosarcoma: influence on patient survival
Cancers 2021, 13(23), 6075.
doi: 10.3390/cancers13236075
Impact factor: 6.639 (2020) Q1 (Oncology)

Fortes-Andrade T, Almeida JS, Sousa LM, Santos-Rosa M, Freitas-Tavares P, Casanova JM, Rodrigues‑Santos P.
The role of Natural Killer cells in Soft Tissue Sarcoma: prospects for immunotherapy
Cancers 2021, 13(15), 3865.
doi: 10.3390/cancers13153865
Impact factor: 6.639 (2020) Q1 (Oncology)

Sousa LM, Almeida JS, Fortes-Andrade T, Santos-Rosa M, Freitas-Tavares P, Casanova JM, Rodrigues‑Santos P.
Tumor and peripheral immune status in Soft Tissue Sarcoma: implications for immunotherapy
Cancers 2021, 13(15), 3885.
doi: 10.3390/cancers13153885
Impact factor: 6.639 (2020) Q1 (Oncology)

Mendes J, Rodrigues‑Santos P, Areia AL, Almeida JS, Alves V, Santos-Rosa M, Mota-Pinto A.
Type 2 and type 3 innate lymphoid cells at the maternal-fetal interface: implications in preterm birth
BMC Immunology 2021, 22:28.
doi: 10.1186/s12865-021-00423-x
Impact factor: 3.615 (2020) Q2 (Immunology)

Cunha Pereira T, Rodrigues‑Santos P, Almeida JS, Rêgo Salgueiro F, Monteiro AR, Macedo F, Félix Soares R, Domingues I, Jacinto P, Sousa G
Immunotherapy and predictive immunologic profile: the tip of the iceberg
Medical Oncology 2021, 38:51.
doi: 10.1007/s12032-021-01497-8
Impact factor: 3.064 (2020) Q2 (Oncology)

Campeão M, Fernandes L, Pita IR, Lemos C, Ali SF, Carvalho F, Rodrigues-Santos P, Fontes-Ribeiro CA, Soares E, Viana SD, Pereira FC.
Acute MDPV binge paradigm on mice emotional behavior and glial signature
Pharmaceuticals 2021, 14(3), 271.
Impact factor: 5.863 (2020) Q1 (Pharmaceutical Sciences)

Mendes JF, Areia AL, Rodrigues-Santos P, Santos-Rosa M, Mota-Pinto A.
Innate Lymphoid cells In Human Pregnancy.
Front Immunol 2020. doi: 10.3389/fimmu.2020.551707
Impact factor: 7.561 (2020) Q1 (Immunology)

Delgado-Silva J, Almeida J, Rodrigues-Santos P, Santos-Rosa M, Gonçalves L.
Activated double-negative T cells (CD3+CD4-CD8-HLA-DR+) define response to renal denervation for resistant hypertension.
Clin Immunol 2020, 218:108521.
Impact factor: 3.969 (2020) Q2 (Immunology)

Lobo ACS, Gomes-da-Silva LC, Rodrigues-Santos P, Cabrita A, Santos-Rosa M, Arnaut LG.
Immune Responses After Vascular Photodynamic Therapy with Redaporfin.
J Clin Med 2020, 9(1):104.
Impact factor: 4241 (2020) Q1 (Medicine, General & Internal)

Almeida JS, Couceiro P, López Sejas N, Alves V, Ruzičková L, Tarazona R, Solana R, Freitas-Tavares P, Santos Rosa M, Rodrigues-Santos P.
NKT-like (CD3+CD56+) cells in Chronic Myeloid Leukaemia patients treated with Tyrosine Kinase Inhibitors.
Front Immunol 2019. doi: 10.3389/fimmu.2019.02493
Impact factor: 5.085 (2019) Q1 (Immunology)

Rodrigues-Santos P, López Sejas N, Almeida JS, Ruzičková L, Couceiro P, Alves V, Campos C, Alonso C, Tarazona R, Freitas-Tavares P, Solana R, Santos Rosa M.
Effect of age on NK cell compartment in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Front Immunol 2018. doi: 10.3389/fimmu.2018.02587
Impact factor: 5.511 (2017) Q1 (Immunology)

Oliveira Miranda C, Marcelo A, Silva TP, Barata J, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Barros I, Alves J, Sereno J, Petrella LI, Castelhano J, Paiva VH, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M, Pereira de Almeida L.
Repeated mesenchymal stromal cell treatment sustainably alleviates Machado-Joseph disease
Mol Ther. 2018 Sep 5;26(9):2131-2151.
Impact factor: 6.688 (2017) Q1 (Molecular Medicine, Molecular Biology, Genetics, Drug Discovery, Pharmacology)

Caetano-Oliveira R, Gomes MA, Abrantes AM, Tavares-Silva E, Oliveira MC, Laranjo M, Queirós DB, Casalta-Lopes J, Pires S, Carvalho L, Gouveia R, Rodrigues-Santos P, Priolli DG, Tralhão JG, Botelho MF.
Revisiting colorectal cancer animal model - An improved metastatic model for distal rectosigmoid colon carcinoma.
Pathophysiology. 2018 Mar 13. pii: S0928-4680(17)30152-9.
Impact factor: 2.910 (2017) Q1 (Pathology and Forensic Medicine, Physiology/medical)

Viana S, Pita I, Lemos C, Rial D, Couceiro P, Rodrigues-Santos P, Caramelo F, Carvalho F, Ali SF, Prediger R, Fontes Ribeiro C, Pereira F.
The effects of physical exercise on non-motor symptoms and on neuroimmune RAGE-network in experimental parkinsonism.
J Applied Physiol 2017, 123(1):161-171.
Impact factor: 3.256 (2017) Q1 (Physiology/medical, Physiology, Medicine/miscellaneous, Sports Science)

Ferreira-Teixeira M, Paiva-Oliveira D, Parada B, Alves V, Sousa V, Chijioke O, Münz C, Reis F, Gomes C, Rodrigues-Santos P.
Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells.
BMC Medicine 2016 14(1):163.
Impact factor: 7.901 (2016) Q1 (Medicine/miscellaneous)

Viana SD, Valero J, Rodrigues-Santos P, Couceiro P, Silva AM, Carvalho F, Ali SF, Fontes-Ribeiro CA, Pereira FC.
Regulation of striatal astrocytic receptor for advanced glycation end-products variants in an early stage of experimental Parkinson's disease.
J Neurochem 2016;138(4):598-609.

Mendes F, Domingues C, Rodrigues-Santos P, Abrantes AM, Gonçalves AC, Estrela J, Encarnação J, Pires AS, Laranjo M, Alves V, Teixo RJ; Sarmento-Ribeiro AB, Botelho MF, Santos-Rosa M.
The role of immune system exhaustion on cancer cells escape and anti-tumor immune induction after irradiation.
Biochim Biophys Acta, 2016; 1865(2):168-175.

Rego Â, Viana SD, Ribeiro CA, Rodrigues-Santos P, Pereira FC.
Monophosphoryl Lipid-A: A Promising Tool for Alzheimer's Disease Toll.
J Alzheimers Dis 2016;52(4):1189-202.

Mazini PS, Alves HV, Reis PG, Lopes AP, Sell AM, Santos-Rosa M, Visentainer JEL and Rodrigues-Santos P
Gene Association with Leprosy: A Review of Published Data.
Front Immunol 2016, 6:658.
Impact factor: 6.429 (2016) Q1 (Immunology)

Areia A, Vale-Pereira S, Alves V, Rodrigues-Santos P, Santos-Rosa M, Moura P, Mota-Pinto A.
Can membrane progesterone receptor alpha on T regulatory cells explain the ensuing human labour?
J Reprod Immunol 2016, 113: 22–26.

Ferreira-Teixeira M, Parada B, Rodrigues-Santos P, Alves V, Ramalho JS, Caramelo F, Sousa V, Reis F, Gomes CM.
Functional and molecular characterization of cancer stem-like cells in bladder cancer: a potential signature for muscle-invasive tumors.
Oncotarget. 2015; 6(34):36185-201.

Rodrigues-Santos P, Santos P, Tralhão JG, Serôdio M, Botelho MF, Pais ML, Castro Sousa F.
Gene expression profile of circulating tumor cells from primary or liver metastatic colorectal cancer.
Hepato-Gastroenterology 2016 (in press)

Areia AL, Vale-Pereira S, Vaz-Ambrósio A, Alves V, Rodrigues-Santos P, Santos Rosa M, Moura P, Mota-Pinto A.
Does progesterone administration in preterm labor influence Treg cells?
J Perinat Med 2016; (6):605-612.

Fonseca NA, Rodrigues AS, Rodrigues-Santos P, Alves V, Gregório AC, Valério-Fernandes A, Gomes-da-Silva LC, Santos Rosa M, Moura V, Ramalho-Santos J, Simões S, Moreira JN.
Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination.
Biomaterials 2015, 69:76–88.

Alves R, Fonseca AR, Gonçalves AC, Ferreira-Teixeira M, Lima J, Abrantes AM, Alves V, Rodrigues-Santos P, Jorge L, Matoso E, Carreira IM, Botelho MF, Sarmento-Ribeiro AB.
Drug Transporters play a key role in the complex process of Imatinib Resistance in vitro.
Leuk Res 2015;39(3):355-60.

Areia AL, Vale-Pereira S, Vaz-Ambrósio A, Alves V, Rodrigues-Santos P, Moura P, Mota Pinto A.
Membrane progesterone receptors in human regulatory T cells: a reality in pregnancy.
BJOG 2015. DOI: 10.1111/1471-0528.13294.

Sereno J, Rodrigues-Santos P, Vala H, Rocha-Pereira P, Alves R, Fernandes J, Santos-Silva A, Carvalho E, Teixeira F, Reis F.
Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model.
Int J Mol Sci. 2014 May 20;15(5):8979-97.

Sereno J, Nunes S, Rodrigues-Santos P, Vala H, Rocha-Pereira P, Fernandes J, Santos-Silva A, Teixeira F, Reis F.
Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat – focus on serum, urine, gene and protein renal expression biomarkers.
BioMed Res Int 2014; 576929.

Coirada F, Couceiro P, Mazini P, Gomes-Silva D, Alves V, Visentainer JEL, Santos-Rosa M, Freitas-Tavares P, Rodrigues-Santos P.
CD137 (4-1BB) as therapeutic target in Chronic Myeloid Leukemia: immunophenotyping, gene expression profile and functional studies in lymphocyte subsets on patients treated with imatinib mesylate.
Rev Port Pneumol 2014, 20:1-7.

Couceiro P, Soverini S, Gomes-Silva D, Freitas-Tavares P, Rodrigues-Santos P.
Screening of ABL kinase domain mutations in Chronic Myeloid Leukemia using Next-Generation Sequencing: impact in monitoring response to tyrosine kinase inhibitor therapy.
Rev Port Pneumol 2014, 20:8-32.

Marques C, Mega AC, Gonçalves A, Rodrigues-Santos P, Teixeira-Lemos E, Teixeira F, Fontes-Ribeiro C, Reis F, Fernandes R.
Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals
Mediators Inflamm 2014, 538737.

Mega C, Vala H, Rodrigues-Santos P, Oliveira J, Teixeira F, Rosa Fernandes, Reis F, Teixeira-Lemos E.
Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties.
Diabetology & Metabolic Syndrome 2014, 6:42.

Bustin S, Benes V, Garson J, Abreu M, Ferreira-Teixeira M, Rodrigues-Santos P et al.
The need for transparency and good practices in the qPCR literature.
Nature Methods 2013; 10(11):1063-1067.

Abreu MT, Carvalheiro H, Rodrigues-Sousa T, Domingos A, Segorbe-Luís A, Souto-Carneiro MM.Rodrigues-Santos P.
Alterations in the peripheral blood B cell subpopulations of multidrug resistant tuberculosis patients.
Clin Exp Med 2013, DOI 10.1007/s10238-013-0258-1.

Sereno J, Parada B, Rodrigues-Santos P, Lopes PC, Carvalho E, Vala H, Teixeira-Lemos E, Alves R, Figueiredo A, Mota A, Teixeira F, Reis F.
Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: cyclosporine versus sirolimus.
Transplant Proc. 2013;45(3):1149-56.

Silva D, Couceiro P, Ferreira-Teixeira M, Tavares P, Sá H, Rodrigues-Santos P.
IL-2, IL-12 and IL-15 prevent reactive oxygen species accumulation on Natural Killer cells from Chronic Myeloid Leukaemia patients following interferon-alpha, imatinib and dasatinib therapy
Rev Port Pneumol. 2013;19:17.

Teixeira-Lemos E, Teixeira HM, Piloto N, Teixeira M, Parada B, Rodrigues-Santos P, Carvalho L, Alves R, Costa E, Belo L, Santos-Silva A, Teixeira F, Reis R.
Cardiometabolic Injury Due to Recombinant Human Erythropoietin Doping for Improvement of Sports Performance: Chronic (Training) versus Acute (Extenuating) Aerobic Exercise.
In: Bastos JH, Silva AC, editors. Athlete Performance and Injuries: Nova Science Pub Inc; 2012. p. 99-121.

Couceiro P, Ferreira Teixeira M, Freitas Tavares P, Rodrigues Santos P.
Screening of ABL kinase domain mutations using high-resolution melting in Chronic Myeloid Leukaemia: impact in the response to treatment with tyrosine kinase inhibitors
Rev Port Pneumol. 2013;19:17.

Barbosa M, Lopes A, Mota C, Mota MC, Oliveira J, Rodrigues-Santos P, De Bonis P, Bisceglia L, Cardoso ML.
Clinical, Biochemical and Molecular characterization of Cystinuria in a cohort of 12 patients
Clin Genet. 2012 Jan;81(1):47-55.

M Reis Silva, C Oliveira, P Rodrigues-Santos, L Carvalho
Genotypes of Helicobacter pylori in Gastric Cancer and Chronic Gastritis
GE J Port Gastroenterol 2011; 5: 218-225.

M Teixeira, P Rodrigues-Santos, P Garrido, E Costa, B Parada, J Sereno, R Alves, L Belo, F Teixeira, A Santos-Silva, F Reis
Cardiac antiapoptotic and proproliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat
J Pharm Bioallied Sci. 2012 Jan;4(1):76-83.

I Velada, F Capela-Silva, F Reis, E Pires, C Egas, P Rodrigues-Santos, MT Barros
Expression of Genes Encoding Extracellular Matrix Macromolecules and Metalloproteinases in Avian Tibial Dyschondroplasia
J Comp Pathol. 2011 Aug-Oct;145(2-3):174-86.

B Parada, F Reis, A Figueiredo, P Nunes, E Teixeira-Lemos, P Garrido, J Sereno, R Pinto, M FX Cunha, P Neto, P Santos, I Velada, A Mota, F Teixeira.
Inhibition of Bladder Tumour Growth by Sirolimus in an Experimental Carcinogenesis Model.
Br J Urology 2011, 107:135-143.

J Sereno, B Parada, F Reis, F Xavier-Cunha, E Teixeira-Lemos, PGarrido, R Pinto, P Rocha-Pereira, P Neto, P Rodrigues-Santos, S Nunes, A Mota,A Figueiredo, F Teixeira
Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model
Mediators of Inflamm 2010: Article ID 380937.

B Raposo, P Rodrigues-Santos, H Carvalheiro, A Agua-Doce, L Carvalho, JA Pereira da Silva, L Graça, M Souto-Carneiro
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis
Arthritis Rheum 2010, 62(10): 2953-2962.

A Henriques, L Inês, M Couto, S Pedreiro, C Santos; M Magalhães, P Santos, I Velada, A Almeida, T Carvalheiro, P Laranjeira, J Morgado, ML Pais, JP Silva, A Paiva.
Frequency and Functional Activity of Th17, Tc17 and other T cell subsets in Systemic Lupus Erythematosus.
Cell Immunol 2010, 264(1):97-103.

JA Hollenbach, A Meenagh, C Sleator, C Alaez, M Bengoche, A Canossi, G Contreras, L Creary, I Evseeva, C Gorodezky, R-A Hardie, T Hemming Karlsen, B Lie, M Luo, M Martinetti, C Navarette, D CM de Oliveira, G Ozzella, A Pasi, E Pavlova, S Pinto, LC Porto, P Santos, A Slavcev, D Srinak, S Tavoularis, S Tonks, E Trachtenberg, S Vejbaesya & D Middleton.
Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.
Tissue Antigens 2010, 76(1):9-17.

AM Teixeira, P Garrido, P Santos, R Alves R, Parada B, Costa E, Almeida A, Teixeira-Lemos E, Sereno J, Pinto R, Belo L, Santos-Silva A, Teixeira F, Reis F.
Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure.
Ren Fail. 2010;32(9):1073-80.

L Geraldes, J Morgado, A Almeida, A Todo-Bom, P Santos, A Paiva, C Chieira, ML Pais
Different patterns of gene expression of CD4+/CD25++/CD127low Regulatory T-cells HLA-DR+
or HLA-DR- in allergy
J Investig Allergol Clin Immunol. 2010;20(3):201-9.

L Ferreira, E Teixeira de Lemos, AF Pinto, B Parada, R Pinto, P Santos, C Mega, H Vala, Garrido P, Sereno J, Melo A, Teixeira F, Reis F
Sitagliptin treatment corrects the cardiometabolic dysfunction in an animal model of type 2 diabetes (ZDF rat)
Mediators Inflamm 2010 (doi:10.1155/2010/592760)

A Almeida, P Santos, A Cabrita, R Alves
The sex influence in chronic kidney disease. Teachings from a genomic approach to fibrosis in experimental obstructive nephropathy
Port J Nephrol Hypert 2010; 24(3).

M Silva, D Azenha, C Pereira, A Almeida, S Balseiro, AM Sampaio, P Santos, L Carvalho.
Gastric carcinoma and chronic gastritis: epigenetic regulation of CDH1 (E-Cadherin), CDNK2A (P16INK4A), PTGS2 (COX2) and EGFR genes through methylation.
Acta Med Port. 2010; 23(1):005-014.

P Garrido, E Costa, E Texeira-Lemos, B Parada, M Teixeira, P Santos, N Piloto, P Sereno, R Alves, R Pinto, P Rocha-Pereira, A Figueiredo, S Nunes, AMP Romão, L Carvalho, P Couceiro, L Belo, A Santos-Silva, F Teixeira, F Reis.
Hemorheological, biochemical and cardiovascular characterization of a rat model of moderate chronic kidney disease.
Bol Soc Port Hemorreol Microcir 2010, 25(2): 9-22.

N Piloto, HM Teixeira, P Garrido, E Teixeira-Lemos, M Teixeira, B Parada, J Sereno, R Pinto, R Alves, P Santos, AM Romão, S Nunes, P Neto, L Carvalho, P Couceiro, F Xavier, P Rocha-Pereira, E Costa, L Belo, A Santos-Silva, F Teixeira, F Reis.
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping.
Bol Soc Port Hemorreol Microcir 2010, 25(1): 11-22.

C Simões, A Almeida, P Santos, A Paiva.
CCR7 e CXCR4 expression and cyclin D1 mRNA expression in mantle cell lymphoma and B cell chronic lymphocytic leukemia.
Rev Port Cienc Biomed 2010; V(5): 10-15.

C Camacho, L Carvalho, L Pereira, E Maia, M J Araújo, R Cortes, P Santos.
MBL in chronic infection by hepatitis B virus: structural and promoter genetic polymorphisms and its correlations with plasmatic levels of oligomeric forms.
Rev Port Cienc Biomed 2010; V(5): 22-27.

L Vicente, AP Rodrigues, AP Galante, E Silva, F Simões, I Marques, H Gonçalves, P Santos
Searching for Cytomegalovirus DNA after leukofiltration of blood transfusion units.
Rev Port Cienc Biomed 2010; V(5): 34-37.

A Almeida, R Alves, P Santos
Experimental models of chronic renal disease by obstruction: functional genomics point of view
Rev Port Cienc Biomed 2009; IV(4): 24-31.

R Leite, R Mareco, C Faustino, P Santos
HLA-B*27: high-resolution molecular information and immunopathology
Rev Port Cienc Biomed 2009; IV(4): 40-44.

AI Duarte, P Santos, CR Oliveira, MS Santos, AC Rego.
Insulinneuroprotection against oxidative stress is mediated by Akt and GSK-3βsignalling pathways and changes in protein expression.
Biochem Biophys Acta - Mol Cell Res 2008; 1793(6):994-1002.

MR Silva, A Sampaio, A Almeida, S Balseiro, P Santos, L Carvalho
Identification of IL1B, IL1RN and TNFA gene polymorphisms in chronic gastritis associated with Helicobacter pylori infection and gastric carcinoma.
GE - J Port Gastroenterol 2008;15:8-15.

A Sampaio, P Santos
Factores genéticos do Helicobacter pylori e do hospedeiro na carcinogenese gástrica
Rev Port Cienc Biomed 2008; III(3): 72-78.